Monday, November 10, 2008

Synthetic Hormones Used in Induced Breeding

Human Chorionic Gonadotropin (HCG):

Human Chorionic Gonadotropin (HCG) is a glycoprotein hormone produced by the placenta in pregnant women. During early pregnancy the hormone appears in the urine in large quantities. When it is injected to the mature fish, the hormone is known to cause the release of gametes. It is thought that the action of releasing gametes is due to the joint action of pituitary glands hormone and HCG. Generally when HCG is injected singly it does not give good result. So it is injected with pituitary gland extract.

In India the use of HCG was started late in 1980s. Both Indian and Chinese carps show good result.

HCG is cheap compare to pituitary extract and has long shelf life. The product is grinded in distilled water (2mg in 0.2ml) and centrifuged. The supernatant is used as injection. The first injection is given to female followed by second dose of injection in both male and female. In second dose the mixture of HCG and pituitary is used. The dose is weight dependent.

Other New Generation Drugs:

A number of new generation drugs are also be used in place of pituitary gland extract. These are very efficient even in lower doses also and cheaply available. Some important drugs are –

Ovaprim (Salmon Gonadotropin): “Ovaprim” is a very efficient drug in place of pituitary extract produced by salmon Gonadotropin RH and Domperidon. It is available in India after 1988 and extensively used. In India good result is shown in West Bengal, Madhya Pradesh, Andhra Pradesh, Karnataka, Kerala, Orissa, and Maharashtra. This hormone is given in very low quantity to the IMC which gives best result. The results suggest that intervention of “Ovaprim” holds considerable promise in future. It is the product of Syndal Lab. Ltd. Canada, distributed in India by Glaxo India Ltd. Mumbai.

Pimozide: It is a dopamine antagonist having ovulatory role of LH-RH- A. It is quite effective in IMC. The LH-RH (Luteinising Hormone – Releasing Hormone) and its analogue LH-RH- A are very effective on brackish water fish – Mugil and Lates. They are cheap but the hormones are short lived.

DOC A: (II-Desoxycorticosterone-acetate) is another very effective drug which has been tried in cat fishes – Clarias & Heteropneustes. They not only help in ovulation but also in maturation of eggs. However, the commercial importance is low due to the high cost.

Anti oestrogen tamoxifen (anti androgen): This hormone gives promising result in Coho-salmon especially when it is administered with pituitary extract. This anti androgen can bring early ovulation. Still the hormone is in experimental result.

2 comments:

Unknown said...

how i get ovaprime in kerala pleasev send whatsap message
to 9895427718

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